Bayesian methods including nonrandomized study data increased the efficiency of postlaunch RCTs

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Bayesian methods including nonrandomized study data increased the efficiency of postlaunch RCTs.

OBJECTIVES Findings from nonrandomized studies on safety or efficacy of treatment in patient subgroups may trigger postlaunch randomized clinical trials (RCTs). In the analysis of such RCTs, results from nonrandomized studies are typically ignored. This study explores the trade-off between bias and power of Bayesian RCT analysis incorporating information from nonrandomized studies. STUDY DESI...

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ژورنال

عنوان ژورنال: Journal of Clinical Epidemiology

سال: 2015

ISSN: 0895-4356

DOI: 10.1016/j.jclinepi.2014.11.015